Kipoi - Seminar

The monthly virtual seminar series is designed as a platform for interested Kipoi users and developers and will host talks on the applications of deep learning on biological data. The seminar is held on every first Wednesday of the month at 5:30 p.m. - 6:30 p.m. CET. We are also happy to share the recordings of the seminar on YouTube.

How to take part

The Virtual Seminar Series takes place via Zoom. To take part in the seminar, you can register for the online Zoom conference. Your personal join link will be valid for all upcoming lectures of the series.

Register

How to apply as a speaker

The seminar is a great opportunity to present your recent work to a large international audience. If you want to apply as a speaker, please use the contact in the registration confirmation email.

Next seminar

Title: Predicting expression-altering promoter mutations with deep learning

7 January 2026 5:30 p.m. - 6:30 p.m. Central European Time

Speaker: Kishore Jaganathan, Illumina

Abstract:

Only a minority of patients with rare genetic diseases are currently diagnosed by exome sequencing, suggesting that additional unrecognized pathogenic variants may reside in non-coding sequence. Here, we describe PromoterAI, a deep neural network that accurately identifies non-coding promoter variants which dysregulate gene expression. We show that promoter variants with predicted expression-altering consequences produce outlier expression at both RNA and protein levels in thousands of individuals, and that these variants experience strong negative selection in human populations. We observe that clinically relevant genes in rare disease patients are enriched for such variants and validate their functional impact through reporter assays. Our estimates suggest that promoter variation accounts for 6% of the genetic burden associated with rare diseases.

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